When oral therapy is not feasible, and the strength, dosage form and route of administration of the drug reasonably lend the preparation to the treatment of the condition, A-Methapred (methylprednisolone sodium succinate) sterile powder is indicated for intravenous or intramuscular use in the following conditions:

1. Endocrine Disorders
   • Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the drug of choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy, mineralocorticoid supplementation is of particular importance)
   • Acute adrenocortical insufficiency (hydrocortisone or cortisone is the drug of choice; mineralocorticoid supplementation may be necessary, particularly when synthetic analogs are used)
   • Preoperatively and in the event of serious trauma or illness, in patients with known adrenal insufficiency or when adrenocortical reserve is doubtful
   • Shock unresponsive to conventional therapy if adrenocortical insufficiency exists or is suspected
   • Congenital adrenal hyperplasia
   • Hypercalcemia associated with cancer
   • Nonsuppurative thyroiditis
2. Rheumatic Disorders 
   As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in:
   • Post-traumatic osteoarthritis
   • Synovitis of osteoarthritis
   • Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy)
   • Acute and subacute bursitis
   • Epicondylitis
   • Acute nonspecific tenosynovitis
   • Acute gouty arthritis
   • Psoriatic arthritis
   • Ankylosing spondylitis
3. Collagen Diseases 
   During an exacerbation or as maintenance therapy in selected cases of:
   • Systemic lupus erythematosus
   • Systemic dermatomyositis (polymyositis)
   • Acute rheumatic carditis
4. Dermatologic Diseases
   • Pemphigus
   • Severe erythema multi-forme (Stevens-Johnson syndrome)
   • Exfoliative dermatitis
   • Bullous dermatitis herpetiformis
   • Severe seborrheic dermatitis
   • Severe psoriasis
   • Mycosis fungoides
5. Allergic States 
   Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in:
   • Bronchial asthma
   • Contact dermatitis
   • Atopic dermatitis
   • Serum sickness
   • Seasonal or perennial allergic rhinitis
   • Drug hypersensitivity reactions
   • Urticarial transfusion reactions
   • Acute noninfectious laryngeal edema (epinephrine is the drug of first choice)
6. Ophthalmic Diseases 
   Severe acute and chronic allergic and inflammatory processes involving the eye, such as:
   • Herpes zoster ophthalmicus
   • Iritis, iridocyclitis
   • Chorioretinitis
   • Diffuse posterior uveitis and choroiditis
   • Optic neuritis
   • Sympathetic ophthalmia
   • Anterior segment inflammation
   • Allergic conjunctivitis
   • Allergic corneal marginal ulcers
   • Keratitis
7. Gastrointestinal Diseases
   To tide the patient over a critical period of the disease in:
   • Ulcerative colitis (systemic therapy)
   • Regional enteritis (systemic therapy)
8. Respiratory Diseases
   • Symptomatic sarcoidosis
   • Berylliosis
   • Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy
   • Loeffler's syndrome not manageable by other means
   • Aspiration pneumonitis
9. Hematologic Disorders
   • Acquired (autoimmune) hemolytic anemia
   • Idiopathic thrombocytopenic purpura in adults (IV only; IM administration is contraindicated)
   • Secondary thrombocytopenia in adults
   • Erythroblastopenia (RBC anemia)
   • Congenital (erythroid) hypoplastic anemia
10. Neoplastic Diseases 
    For palliative management of:
    • Leukemias and lymphomas in adults
    • Acute leukemia of childhood
11. Edematous States
• To induce diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupuserythematosus
12. Nervous System
• Acute exacerbations of multiple sclerosis
13. Miscellaneous
    • Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy
    • Trichinosis with neurologic or myocardial involvement